Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of the Lymphatic System01:15

Development of the Lymphatic System

2.8K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.8K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

3.1K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.1K
Inflammation01:38

Inflammation

46.6K
Overview
46.6K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

6.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
6.9K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

14.4K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
14.4K
Development of Immunocompetence01:22

Development of Immunocompetence

1.2K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recent increase in N<sub>2</sub>O growth rate (2013-2023) mainly due to increase of nitrogen-fertiliser and manure use in the Northern Tropics and Southern Landmass.

Geoscience letters·2026
Same author

Land vertebrates increasingly exposed to multiple extreme events by 2085.

Nature ecology & evolution·2026
Same author

An Anti-Cell Adhesion Molecule 1 Antibody Improves Mite Antigen-Induced Atopic Dermatitis-Like Lesions and Pruritus in NC/Nga Mice.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre·2026
Same author

Spatial single-cell proteotyping reveals immunotherapy-resistant features within the complex tumor microenvironment of metastatic NSCLC.

The Journal of clinical investigation·2026
Same author

Cell adhesion molecule 1 is upregulated in connective tissue mast cells and potentially contributes in IgE-mediated degranulation.

Scientific reports·2026
Same author

Harmonized global soil carbon and respiration datasets with derived turnover time and temperature sensitivity.

Scientific data·2025
Same journal

Exocarpium Citri Grandis oil relieves depressive-like behaviors via neurotransmitter and inflammatory pathway modulation.

Proceedings of the Japan Academy. Series B, Physical and biological sciences·2026
Same journal

Glyoxalase activities of Parkinson's disease relevant protein DJ-1/PARK7: Past discoveries and future perspectives.

Proceedings of the Japan Academy. Series B, Physical and biological sciences·2026
Same journal

Structural and dynamic heterogenization and phase transition in plastic crystal phase: Taking a representative molecular plastic crystal and an ionic one as examples.

Proceedings of the Japan Academy. Series B, Physical and biological sciences·2026
Same journal

Design principles for hydrogen-embrittlement-resistant FCC alloys: solution-treated steels and Ni-Cr-Fe alloys -An overview.

Proceedings of the Japan Academy. Series B, Physical and biological sciences·2026
Same journal

Extraterrestrial <sup>3</sup>He flux variability during the Triassic recorded in pelagic bedded cherts of Japan.

Proceedings of the Japan Academy. Series B, Physical and biological sciences·2026
Same journal

Extremely active Sun from 1190 to 1220 in the Medieval Period: Intercomparison of historical records and tree-ring carbon-14.

Proceedings of the Japan Academy. Series B, Physical and biological sciences·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

9.8K

Development of mast cells.

Yukihiko Kitamura1, Keisuke Oboki2, Akihiko Ito3

  • 1Developmental Research Laboratories, Shionogi Co., Ltd., Futaba-cho 3-1-1, Toyonaka, Osaka 561-0825, Japan . ; Recipient of Japan Academy Prize in 2005.

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
|December 25, 2013
PubMed
Summary
This summary is machine-generated.

Mast cells develop from hematopoietic stem cells and differentiate based on tissue location. Connective tissue-type mast cells can proliferate even after maturation and degranulation, offering therapeutic potential.

Keywords:
KITMITFallergybasophilhematopoietic stem cellmast cell

More Related Videos

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
11:31

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

11.6K
Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

11.8K

Related Experiment Videos

Last Updated: May 4, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

9.8K
Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
11:31

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

11.6K
Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

11.8K

Area of Science:

  • Immunology
  • Cell Biology
  • Hematopoiesis

Background:

  • Mast cells originate from multipotential hematopoietic stem cells (MHSCs).
  • Mast cell progenitors (MCPs) migrate from hematopoietic tissues to various connective and mucosal tissues.
  • Mast cell phenotype (connective tissue-type or mucosal type) is determined by their lodging site.

Purpose of the Study:

  • To elucidate the developmental pathway and characteristics of mast cells.
  • To investigate the role of KIT signaling in mast cell development and function.
  • To explore the therapeutic potential of targeting mast cell development.

Main Methods:

  • Descriptive analysis of mast cell development and differentiation.
  • Review of the role of KIT ligand and KIT receptor tyrosine kinase.
  • Examination of KIT gene mutations and their effects on mast cell populations.

Main Results:

  • Connective tissue-type mast cells (CTMCs) exhibit significant proliferation potential post-maturation and degranulation.
  • KIT ligand is crucial for mast cell development and survival.
  • KIT gene mutations lead to mast cell depletion (loss-of-function) or tumors (gain-of-function).

Conclusions:

  • Mast cell development is a dynamic process influenced by microenvironmental cues.
  • The KIT pathway is a critical regulator of mast cell homeostasis.
  • Modulating mast cell development presents a promising therapeutic strategy for various diseases.