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The changes in the endothelial function and haemostatic and inflammatory parameters in subclinical and overt
Anna Popławska-Kita1, Katarzyna Siewko1, Beata Telejko1
1Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Sklodowskiej-Curie 24A, 15-276 Białystok, Poland.
International Journal of Endocrinology
|December 25, 2013
Summary
Subclinical and overt hyperthyroidism are linked to endothelial dysfunction, indicated by elevated inflammation markers. Overt hyperthyroidism shows higher levels of specific inflammatory markers compared to subclinical forms.
Area of Science:
- Endocrinology
- Cardiovascular Science
- Immunology
Background:
- Hyperthyroidism, including Graves' disease and toxic nodular goiter, impacts various physiological systems.
- Endothelial dysfunction and low-grade inflammation are implicated in cardiovascular complications.
Purpose of the Study:
- To compare circulating markers of endothelial function and inflammation in subclinical hyperthyroidism (SH) and overt hyperthyroidism (OH).
- To investigate differences between Graves' disease (GD) and toxic nodular goiter (TNG) in relation to these markers.
Main Methods:
- Study included 42 patients with GD, 75 with TNG, and 39 healthy controls.
- Measured circulating markers of endothelial dysfunction and inflammation, including interleukins (IL-6, IL-12, IL-18), von Willebrand factor (vWF), and fibrinogen.
Main Results:
- Elevated endothelial dysfunction markers were observed in both SH and OH groups.
- Overt hyperthyroidism (OH) showed significantly higher levels of IL-12, IL-18, fibrinogen, and vWF compared to SH.
- Graves' disease patients exhibited the highest levels of IL-6, IL-12, IL-18, vWF, sVCAM-1, and fibrinogen, though not significantly different from TNG.
Conclusions:
- Both SH and OH are associated with endothelial dysfunction, characterized by impaired fibrinolysis and hypercoagulability.
- Increased levels of IL-6, IL-12, and IL-18 correlate with hyperthyroidism severity and degree.
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