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Updated: May 4, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Flow microreactor synthesis in organo-fluorine chemistry
Hideki Amii1, Aiichiro Nagaki2, Jun-Ichi Yoshida2
1Division of Molecular Science, Graduate School of Science and Technology, Gunma University, Tenjin-cho, Kiryu, Gunma 376-8515, Japan.
Abstract:
Organo-fluorine compounds are the substances of considerable interest in various industrial fields due to their unique physical and chemical properties. Despite increased demand in wide fields of science, synthesis of fluoro-organic compounds is still often faced with problems such as the difficulties in handling of fluorinating reagents and in controlling of chemical reactions. Recently, flow microreactor synthesis has emerged as a new methodology for producing chemical substances with high efficiency. This review outlines the successful examples of synthesis and reactions of fluorine-containing molecules by the use of flow microreactor systems to overcome long-standing problems in fluorine chemistry.
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