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The effect of exogenous creatine phosphate on myocardial injury after percutaneous coronary intervention
Deng Ke-Wu1, Shi Xu-Bo2, Zhao Ying-Xin3
1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China Department of Cardiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Objective:
To evaluate the effect of exogenous creatine phosphate (CP) on myocardial injury after percutaneous coronary intervention (PCI).
Method:
Four hundred patients were divided to receive conventional therapy (control group) or 3-day intravenous infusion of CP after PCI (CP group). Levels of creatine kinase MB (CK-MB) and troponin I (TnI) were measured before and on postprocedural day 3.
Results:
Postprocedural CK-MB and TnI in the CP group were significantly increased compared to the control group. In the CP group, 8.0% and 5.0% of patients had an increase in CK-MB 1 to 3 times and >3 times, respectively, which were significantly lower than that of the control group (19.0% and 9.0%, respectively); 12.0% and 10.0% of patients had an increase in TnI 1 to 3 times and >3 times, respectively, which were significantly lower than that of the control group (21.0% and 18.0%, respectively).
Conclusion:
Exogenous CP was helpful to reduce myocardial injury after PCI.
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