[Preparation and possibilities for pharmaceutical use of nano- and microfiber systems I]

The application of nanoactive drugs and nanostructured drug delivery systems enables the increase of bioavailability of active agents of unfavorable physical and chemical characteristics, thus assuring the basis of the cost-effective therapy. Fiber formation procedures (high speed rotary/centrifugal spinning, blow/jet spinning, electrospinning, melt spinning, emulsion spinning) have long been known to create micro-and nano-size range polymeric fibers, while in the pharmaceutical industry they still seldom applied, therefore their implementation provides new opportunities mainly in the field of pharmaceutical technology. The present paper provides an overview of different types of spinning methods and their principle. The manuscript compares the spinning technologies, points out their advantages and limitations, and highlights the potential opportunities for pharmaceutical use, as well.