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Selective and sensitive superoxide detection with a new diselenide-based molecular probe in living breast cancer
Sudesh T Manjare1, Sungsoo Kim, Won Do Heo
1Center for Catalytic Hydrocarbon Functionalizations, Institute for Basic Science (IBS) , 373-1 Guseong-dong, Yuseong-gu, Daejeon, 305-701, Republic of Korea.
Organic Letters
|December 28, 2013
Abstract:
A diselenide-based BODIPY probe was prepared; it was found to be sensitive and selective for superoxide in giving [-Se(O)Se(O)-] oxidation. Probing was reversible through the use of biothiols; (77)Se NMR and other types of spectroscopy were employed. Practical medicinal utility was demonstrated in MCF-7/ADR cancer cells.
