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Published on: August 12, 2019
Rh(III)-catalyzed C-H amidation with N-hydroxycarbamates: a new entry to N-carbamate-protected arylamines
Bing Zhou1, Juanjuan Du, Yaxi Yang
1Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu Chong Zhi Road, Shanghai 201203, PR China.
Abstract:
An unprecedented Rh(III)-catalyzed direct intermolecular C-H amidation with N-hydroxycarbamates has been developed. Different directing groups, such as pyridine, pyrimidine, pyrazole, and N-OMe oxime, can be employed in this C-H amidation process, providing valuable N-carbamate-protected arylamines (e.g., Cbz, Moz, Ac, Boc, and Fmoc). More importantly, this process may afford a new avenue for intermolecular C-H amidation where readily available N-hydroxycarbamates can be used as the nitrogen source.
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