Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Not Just Half a Doctor: Promoting Humanism During Stressful Times.

Annals of the Child Neurology Society·2026

Same author

The Role of Academic Medical Centers in Personalized Experimental Therapeutic Development: Key Considerations.

Neurology·2026

Same author

Interferon Restores Antigen Presentation and Sensitizes Medulloblastoma to T Cell Killing.

bioRxiv : the preprint server for biology·2025

Same author

An Approach to Successful Development of Clinician-Scientists in Neurology: The NINDS R25 Experience.

Annals of neurology·2024

Same author

WNT signalling control by KDM5C during development affects cognition.

Nature·2024

Same author

Developmental basis of SHH medulloblastoma heterogeneity.

Nature communications·2024

Search research articles

Related Experiment Video

Updated: May 4, 2026

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

A developmental program drives aggressive embryonal brain tumors.

Tenley C Archer¹, Scott L Pomeroy¹

¹Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Nature Genetics

|December 28, 2013

Summary

This summary is machine-generated.

Embryonal tumors with multilayered rosettes (ETMRs), a rare infant cancer, are driven by a specific gene promoter fusion. This fusion activates a fetal neural development program, offering new insights into these primitive neuroectodermal tumors.

More Related Videos

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

Published on: August 12, 2014

Transplantation of Zebrafish Pediatric Brain Tumors into Immune-competent Hosts for Long-term Study of Tumor Cell Behavior and Drug Response

Transplantation of Zebrafish Pediatric Brain Tumors into Immune-competent Hosts for Long-term Study of Tumor Cell Behavior and Drug Response

Published on: May 17, 2017

Related Experiment Videos

Last Updated: May 4, 2026

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

Published on: August 12, 2014

Transplantation of Zebrafish Pediatric Brain Tumors into Immune-competent Hosts for Long-term Study of Tumor Cell Behavior and Drug Response

Transplantation of Zebrafish Pediatric Brain Tumors into Immune-competent Hosts for Long-term Study of Tumor Cell Behavior and Drug Response

Published on: May 17, 2017

Area of Science:

Neuro-oncology
Developmental neurobiology
Genomics

Background:

Embryonal tumors with multilayered rosettes (ETMRs) are aggressive pediatric brain tumors.
The molecular drivers of ETMRs have remained largely elusive.

Discussion:

This study identifies a universal mechanism driving ETMRs.
The fusion event links a brain-specific gene promoter to a microRNA cluster, dysregulating neural development.

Key Insights:

ETMRs are driven by the fusion of the TTYH1 promoter to the C19MC microRNA cluster.
This fusion aberrantly activates a fetal neural development program.
The findings provide a unified molecular basis for ETMR pathogenesis.

Outlook:

Understanding this mechanism may lead to targeted therapies for ETMRs.
Further research into the C19MC cluster's role in neural development is warranted.