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Hepatocyte growth factor in patients with coronary artery disease and its relation to periodontal condition

J Lönn1, C Starkhammar Johansson2, H Kälvegren3

  • 1Division of Clinical Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden ; PEAS Institute, Linköping, Sweden.

Results in Immunology
|December 28, 2013
PubMed

Insights

Elevated Hepatocyte Growth Factor (HGF) in coronary artery disease (CAD) patients may signal chronic inflammation. Despite high HGF levels, its reduced biological activity suggests impaired tissue repair in CAD and periodontitis.

Area of Science:

  • Cardiovascular Research
  • Oral Health
  • Biochemistry

Background:

  • Hepatocyte Growth Factor (HGF) is vital for tissue repair and vascularization.
  • Elevated HGF levels correlate with chronic inflammatory conditions like coronary artery disease (CAD) and periodontitis.
  • Reduced biological activity of HGF is observed in chronic inflammation, potentially impacting its binding to heparan sulfate proteoglycan (HSPG).

Purpose of the Study:

  • To evaluate serum HGF concentration and biological activity in CAD patients before and after percutaneous coronary intervention (PCI).
  • To investigate the relationship between HGF levels, biological activity, and periodontal status in CAD patients.
  • To assess the impact of PCI on HGF dynamics and its association with periodontal health.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) for serum HGF concentration.
  • Surface Plasmon Resonance (SPR) to measure HGF affinity to HSPG, indicating biological activity.
  • Polymerase Chain Reaction (PCR) to detect P. gingivalis in periodontal pockets.
  • Assessment of periodontal status in CAD patients.

Main Results:

  • CAD patients exhibited significantly higher HGF concentrations than controls, irrespective of periodontal status.
  • HGF concentration and HSPG affinity showed adverse fluctuations post-PCI.
  • Biological activity of HGF increased one month after intervention in patients without periodontitis.
  • HGF concentration was independent of periodontal status.

Conclusions:

  • Elevated HGF concentration with reduced biological activity in CAD patients may indicate a chronic inflammatory state.
  • The interplay between HGF, CAD, and periodontitis warrants further investigation.
  • PCI influences HGF dynamics, with potential recovery of biological activity in patients with good periodontal health.

Keywords:
AngiographyCoronary artery diseaseHepatocyte growth factorPeriodontal diseasePorphyromonas gingivalis

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