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Updated: May 4, 2026

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
Published on: December 7, 2014
Prognostic impact of JAK2V617F mutation in myelodysplatic syndromes: A matched case control study
Benoit de Renzis1, Veronique Mansat-De Mas2, Eric Wattel3
1Service d'Hématologie Clinique Adulte et de Thérapie Cellulaire, CHU Estaing, CREaT - EA 7283 INSERM et CIC501 Clermont-Ferrand, France.
Abstract:
While in RARS-T, JAK2V617F mutation is common and associated with good prognosis, the clinical and prognostic impact of this mutation in other MDS is unknown. We collected data from 132 non-RARS-T MDS with known JAK2V617F mutation status. JAK2V617F mutation was significantly correlated with lower progression to AML (p<.0011) and better overall survival (OS, p=.011). OS difference persisted after matching on age, sex, IPSS and % marrow blast (p=.031). Thus, in MDS other than RARS-T, JAK2V617F mutation may be associated with favorable outcome.
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