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Updated: May 4, 2026

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry
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Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry

Published on: July 26, 2019

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Potent phosphatidylinositol 3-kinase inhibitors and their biology

Mukesh Chandra Joshi, Krishan Kumar, Vikrant Kumar1

  • 1Department of Chemistry, Motilal Nehru College, University of Delhi, Delhi-110021, India. mukeshjoshi21@gmail.com.

Current Drug Discovery Technologies
|December 31, 2013
PubMed

Insights

Phosphoinositide 3-kinase (PI3k) regulates cell functions and is often overactive in cancers. Inhibiting this pathway offers a promising cancer therapy strategy, with several PI3k inhibitors in development.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Phosphoinositide 3-kinase (PI3k) is a key regulator of intracellular signaling pathways.
  • These pathways control critical cellular processes including proliferation, migration, survival, and angiogenesis.
  • The PI3k pathway is frequently dysregulated in human cancers, making it a significant therapeutic target.

Purpose of the Study:

  • To review the role of PI3k in cellular functions and cancer.
  • To highlight the therapeutic potential of PI3k inhibitors in cancer treatment.
  • To summarize existing and developing PI3k inhibitors.

Main Methods:

  • Literature review of PI3k signaling pathways.
  • Analysis of PI3k pathway's role in oncogenesis.
  • Survey of reported PI3k inhibitors and their clinical status.

Main Results:

  • PI3k pathway activation is crucial for cell growth and survival.
  • Upregulation of PI3k signaling is a common event in various human cancers.
  • Numerous potent PI3k inhibitors have been identified, with some progressing to clinical trials.

Conclusions:

  • Inhibition of the PI3k pathway represents a promising strategy for cancer therapy.
  • Ongoing research and development of PI3k inhibitors show potential for clinical application.
  • A range of synthetic and natural product-based PI3k inhibitors are under investigation.

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