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Nanoparticle-based tumor theranostics with molecular imaging
Lina Wang, Yuebing Wang, Zongjin Li1
1Nankai University School of Medicine, 94 Weijin Road, Tianjin, 300071, China. zongjinli@nankai.edu.cn.
Abstract:
The past few decades have brought on a dramatic change in the treatment of cancer; however, routine treatments fail to specifically clear tumorigenic cells and may be followed by cancer recurrence. Recent advances in developing multifunctional nanoparticles provide exciting new possibilities for drug delivery used in tumor-targeted therapy. Moreover, molecular imaging is an invaluable tool in evaluating new molecular targets, cancer diagnosis, predicting of tumor response to available therapies and monitoring response to therapy as well as developing new drugs prior to clinical translation. Combining of targeted cancer therapy and molecular imaging, termed as image-guided drug delivery, can achieve objectives of noninvasive assessment of drug biodistribution and real-time monitoring of therapeutic responses. Image-guided drug delivery has become an upcoming field with extensive prospect in cancer therapy and may provide an effective platform for personalized cancer care. This review will focus on the significance and recent advances in targeted and traceable therapeutic strategy for cancer therapy.
Insights
Multifunctional nanoparticles offer new tumor-targeted cancer therapy options. Image-guided drug delivery combines therapy and molecular imaging for personalized cancer care and monitoring treatment response.
Area of Science:
- Oncology
- Nanotechnology
- Medical Imaging
Background:
- Traditional cancer treatments often fail to eliminate all tumor cells, leading to recurrence.
- Multifunctional nanoparticles present novel opportunities for targeted drug delivery in cancer therapy.
- Molecular imaging is crucial for cancer diagnosis, treatment response assessment, and drug development.
Purpose of the Study:
- To review the significance and recent advancements in targeted and traceable therapeutic strategies for cancer therapy.
- To highlight the potential of image-guided drug delivery in personalized cancer care.
Main Methods:
- Review of recent literature on targeted nanoparticles for cancer therapy.
- Discussion of molecular imaging techniques in conjunction with drug delivery.
- Analysis of image-guided drug delivery systems for noninvasive assessment and real-time monitoring.
Main Results:
- Multifunctional nanoparticles enable precise tumor targeting and drug delivery.
- Image-guided drug delivery allows noninvasive monitoring of drug biodistribution and therapeutic effects.
- This combined approach facilitates personalized cancer treatment strategies.
Conclusions:
- Image-guided drug delivery represents a promising frontier in cancer therapy.
- Targeted and traceable therapeutic strategies are essential for improving patient outcomes and reducing recurrence.
- This approach offers a platform for effective personalized cancer care.
