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Updated: May 4, 2026

Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
Vitamin D deficiency among newborns in Amman, Jordan
Najwa Khuri-Bulos, Ryan D Lang, Meridith Blevins
1. natasha.halasa@vanderbilt.edu.
Insights
Over 94% of Jordanian newborns have vitamin D deficiency. Factors like maternal smoking and winter birth are linked to lower vitamin D levels in infants, highlighting the need for supplementation.
Area of Science:
- Neonatal Health
- Nutritional Science
- Public Health
Background:
- Vitamin D deficiency is prevalent in the Middle East.
- Neonatal vitamin D status in Jordan remains understudied.
- Understanding deficiency prevalence and risk factors is crucial for intervention.
Purpose of the Study:
- To determine the prevalence of vitamin D deficiency in Jordanian newborns.
- To identify risk factors associated with low vitamin D levels in this population.
Main Methods:
- Prospective cohort study conducted in Amman, Jordan.
- Collected blood samples from 3,731 newborns within 96 hours of birth for 25-hydroxyvitamin D [25(OH)D] analysis.
- Documented maternal and infant factors including dress pattern, supplementation, smoke exposure, gestational age, and birth weight.
Main Results:
- A high prevalence of vitamin D deficiency (94.1%) was observed, with a median 25(OH)D level of 8.6 nmol/L.
- Lower gestational age, maternal smoke exposure, and winter birth were associated with decreased infant vitamin D levels.
- Maternal vitamin D supplementation and outdoor time during pregnancy correlated with higher infant vitamin D levels.
Conclusions:
- Severely low vitamin D levels are substantial in newborns in Amman, Jordan.
- Deficiency persists even in infants born during warmer months.
- Vitamin D supplementation is recommended for this vulnerable population.
Objective:
Vitamin D deficiency is well recognized in selected Middle Eastern countries, but neonatal vitamin D status is not well studied in Jordan and other nearby countries. The aim of this study is to determine the prevalence of vitamin D deficiency in Jordanian newborns and risk factors associated with low levels.
Methods:
This is a prospective cohort study of newborn infants who were delivered at the Al Bashir Government Hospital in Amman, Jordan, from January 31, 2010, to January 27, 2011. Heel stick blood samples for 25-hydroxyvitamin D [25(OH)D] levels were obtained within 96 hours of birth. Maternal dress pattern, vitamin supplementation, smoke exposure during pregnancy, mode of delivery, gestational age, and birth weight were documented.
Results:
Samples were obtained from 3,731 newborns. Median gestational age was 39 weeks, median birth weight was 3.1 kilograms, median maternal age was 27 years, and median newborn 25(OH)D level was 8.6nmol/L. A total of 3,512 newborns (94.1%) in this study were vitamin D deficient (< 50 nmol/L). Lower gestational age, maternal smoke exposure, and birth during winter months were associated with lower infant vitamin D levels, while vitamin D supplementation and time spent outside during pregnancy were associated with higher vitamin D levels.
Conclusions:
The prevalence of severely low vitamin D levels in newborn infants in Amman, Jordan, is substantial, even in newborns born during the spring and summer months. Vitamin D supplementation is needed in this population.
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