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Contralateral-eye study of surface refractive treatments: clinical and confocal microscopy evaluation
Vasilios F Diakonis1, Vardhaman P Kankariya1, George Kounis1
1From the Institute of Vision and Optics (Diakonis, Kankariya, Kounis, A.I. Pallikaris, I.G. Pallikaris, Kymionis), Department of Medicine, University of Crete, Heraklion, Greece; the Bascom Palmer Eye Institute (Diakonis, Kankariya, Yoo, Kymionis), Miller School of Medicine, University of Miami, Miami, Florida, USA.
Purpose:
To compare the visual and refractive outcomes and the corneal structural changes in myopic patients after surface refractive treatments (ie, photorefractive keratectomy [PRK] with adjuvant mitomycin-C [MMC] and epithelial laser in situ keratomileusis [epi-LASIK]).
Setting:
University of Crete, Heraklion, Crete, Greece.
Design:
Prospective comparative case series.
Methods:
One eye of consecutive myopic patients was randomly assigned to PRK-MMC, and the fellow eye was treated with epi-LASIK. Visual and refractive outcomes and corneal confocal microscopy findings were evaluated. All patients were examined preoperatively and 1, 3, 6, 12, and 24 months postoperatively.
Results:
Twenty-six eyes (13 patients) were included. The mean follow-up was 2.47 years ± 0.35 (SD) (range 1.64 to 2.93 years). In the PRK-MMC group, the mean preoperative spherical equivalent refraction was -3.84 ± 1.59 diopters (D) (range -1.5 to -8.7 D) and -0.21 ± 0.44 D (range -0.5 to 1.0 D) at the last follow-up and in the epi-LASIK group, -3.91 ± 1.48 D (range -1.5 to -8.5 D) and -0.18 ± 0.36 (range +0.5 to -0.5 D), respectively. Qualitative analysis of the subepithelial nerve plexus, haze development, and keratocyte distribution were similar in the 2 groups. There was no statistically significant difference in endothelial cell density between the groups throughout the follow-up (P>.05).
Conclusion:
Epithelial LASIK and PRK-MMC gave similar visual, refractive, and corneal structural outcomes in patients with myopia for up to 2 years postoperatively.
Financial Disclosure:
No author has a financial or proprietary interest in any material or method mentioned.
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