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Updated: May 4, 2026

Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
[Biomarkers in inflammatory bowel diseases]
Xavier Roblin1, Alaric Cavaille2, Léa Clavel1
1CHU de Saint-Étienne, hôpital Nord, service de gastro-entérologie, 42277 Saint-Priest-en-Jarez, France.
Abstract:
Fecal calprotectine is of interest for diagnosis of IBD at the beginning. CRP and fecal calprotectine are predictive of long-term response in patients treated by anti-TNF therapy. Trough levels of anti-TNF are associated to clinical remission and mucosal healing. Detectable antibodies to anti-TNF are associated with lower response to treatment. Interventional studies are waiting before optimization of treatment in function of biomarkers. Trough levels of anti-TNF help to modify our treatment (optimization or de-escalation).
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