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Histopathologic clues for the diagnosis of Wiesner nevus
Mar Llamas-Velasco1, Yosmar Carolina Pérez-Gónzalez2, Luis Requena3
1Department of Dermatology, Hospital Infanta Cristina, Parla, Madrid, Spain.
Abstract:
The dermatologic hallmark of a recently described BAP1-associated cancer susceptibility syndrome is a dome-shaped nevus with distinct clinicopathological features, first delineated by Wiesner and colleagues. Here we describe the leading histopathological criteria of Wiesner nevus. Wiesner nevus is composed of various nevomelanocytic populations all showing different degrees of atypia ranging from hyperchromatic nevus cell-like to large atypical epithelioid cells. Immunohistochemically, Wiesner nevus is BAP1 negative and VE1 positive.
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