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Effect of ageing on tactile transduction processes
Johanna Decorps1, Jean Louis Saumet1, Pascal Sommer1
1Laboratory of Tissue Biology and Therapeutic Engineering, Centre National de la Recherche Scientifique (CNRS) UMR 5305, Lyon, France; University of Lyon 1, UMR 5305, Lyon, France.
Ageing Research Reviews
|December 31, 2013
Summary
Aging significantly impairs touch sensation and perception by affecting skin structures, nerve function, and the central nervous system. This review details age-related changes impacting tactile function in older adults.
Area of Science:
- Neuroscience
- Gerontology
- Dermatology
Background:
- Age-related decline in sensory modalities, particularly touch, is a common observation.
- Understanding these changes is crucial for maintaining quality of life in aging populations.
Purpose of the Study:
- To review the peripheral mechanisms underlying age-related decline in touch sensation and perception.
- To highlight the impact of aging on cutaneous mechanotransduction, sensory innervation, and vascular supply.
- To discuss tools and models for studying tactile deficits in aging.
Main Methods:
- Literature review focusing on peripheral and central nervous system changes related to aging and touch.
- Analysis of morphological and functional alterations in skin and neural components.
- Examination of available experimental models and assessment tools.
Main Results:
- Aging affects cutaneous mechanical transducers, mechanosensitive ion channels, and sensory nerve fibers.
- Changes in neurotransmitters and the skin's vascular system contribute to tactile deficits.
- Skin structure alterations and central nervous system aging exacerbate tactile impairment.
Conclusions:
- Age-associated tactile decline results from multifaceted peripheral and central nervous system changes.
- Further research using appropriate tools and models is needed to fully understand and potentially mitigate these deficits.
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