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Updated: May 4, 2026
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Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis
Published on: November 17, 2020
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Central nervous system lymphoma associated with natalizumab
Angelika Na1, Nick Hall1, Bhadrakant Kavar1
1Department of Neurosurgery, Royal Melbourne Hospital, Parkville, Melbourne, VIC, Australia.
Summary
Primary central nervous system lymphoma (PCNSL) cases following natalizumab treatment are usually coincidental. However, a recent patient’s rapid PCNSL onset suggests a potential causal link, warranting further investigation.
Area of Science:
- Neuro-oncology
- Immunology
Background:
- Primary central nervous system lymphoma (PCNSL) is a rare non-Hodgkin lymphoma.
- Natalizumab is a humanized monoclonal antibody used to treat multiple sclerosis and Crohn's disease.
Observation:
- A case of PCNSL was observed in a patient treated with natalizumab.
- The patient presented with an explosive onset of PCNSL symptoms.
Findings:
- The rapid onset of PCNSL in this patient suggests a potential causal relationship with natalizumab treatment.
- This contrasts with previous assumptions of coincidental occurrences.
Implications:
- This case highlights the need for vigilance regarding potential adverse events associated with natalizumab.
- Further research is warranted to explore a possible causal link between natalizumab and PCNSL development.
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