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Updated: May 4, 2026
12:17
Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.
Published on: March 17, 2008
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Solvent induced phase inversion-based in situ forming controlled release drug delivery implants
Raghu Raj Singh Thakur1, Hannah L McMillan1, David S Jones1
1Drug Delivery and Biomaterials Group, School of Pharmacy, Medical Biology Centre Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, United Kingdom.
Summary
In situ forming implants offer localized drug delivery advantages. This review focuses on solvent-induced phase inversion techniques, discussing polymers, solvents, and burst release reduction strategies for improved drug delivery systems.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Polymer Chemistry
Background:
- In situ forming (ISF) implants are gaining interest for biomedical applications.
- ISF implants offer advantages like localized delivery, less invasive application, and sustained drug action.
- Solvent-induced phase inversion (SPI) is a key technique for ISF implant formation.
Purpose of the Study:
- To critically review polymers, solvents, and co-solvents used in SPI implant preparation.
- To discuss factors affecting burst release and strategies for its reduction.
- To examine biodegradation, stability, characterization, and sterilization of SPI systems.
Main Methods:
- Comprehensive literature review of ISF implants formed via SPI.
- Analysis of polymers, solvents, and co-solvents for controlled drug release.
- Evaluation of strategies to mitigate burst release in SPI systems.
Main Results:
- SPI systems offer tailored drug delivery but face challenges with high burst release.
- Various polymers and biocompatible solvents are effective in SPI implant formulation.
- Modification strategies can significantly reduce burst release from SPI implants.
Conclusions:
- SPI technique is a promising approach for developing advanced drug delivery implants.
- Further research and development are supported by pharmaceutical companies for diverse therapeutic applications.
- This review serves as a comprehensive resource for scientists in the field of SPI drug delivery systems.
Keywords:
Controlled releaseDrug deliveryIn situ forming implantsSolvent induced phase inversion implantsSustained releaseMore Related Videos
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