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Nesprins in health and disease
Sarah Cartwright1, Iakowos Karakesisoglou1
1School of Biological and Biomedical Sciences, University of Durham, Durham DH1 3LE, UK.
Seminars in Cell & Developmental Biology
|December 31, 2013
Summary
The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex, particularly nesprins, connects the nucleus to the cell
Area of Science:
- Cell Biology
- Molecular Biology
- Genetics
Background:
- The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex is a crucial structure spanning the nuclear envelope.
- Nesprins, key LINC complex components, were initially identified as nuclear envelope proteins.
- Nesprin genes produce diverse variants with varied subcellular localizations, suggesting expanded functions.
Purpose of the Study:
- To review the structure, molecular interactions, and cellular functions of nesprins.
- To explore the relevance of nesprin functions to human diseases.
- To speculate on pathomechanisms in nesprin-associated diseases.
Main Methods:
- Literature review of nesprin structure and function.
- Analysis of nesprin involvement in various diseases.
- Speculative analysis of disease mechanisms.
Main Results:
- Nesprins exhibit diverse structures and interactions.
- Nesprin variants are implicated in cancer, myopathies, neurological disorders, and hearing loss.
- Nesprin dysfunctions are linked to multiple pathological conditions.
Conclusions:
- Nesprins play vital roles in fundamental biological processes.
- Nesprin variants and their functions are critical for understanding various diseases.
- Further research into nesprin pathomechanisms could reveal therapeutic targets.
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