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Updated: May 4, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
Daily movement patterns and biological markers among adults in the United States
Paul D Loprinzi1, Hyo Lee2, Bradley J Cardinal3
1Department of Exercise Science, Bellarmine University, Donna & Allan Lansing School of Nursing & Health Sciences, Louisville, KY, USA.
Objective:
To examine the combined effects of sedentary (SED), light (LPA) and moderate-to-vigorous physical activity (MVPA) on biological markers among a nationally representative sample of U.S. adults.
Methods:
Data from the 2003-2006 NHANES study was used, with 5580 adults (≥20years) included in the study. Participants wore an ActiGraph 7164 accelerometer with accelerometry data used to create four movement pattern groups: ≥150min/week of MVPA and LPA≥SED; ≥150min/week of MVPA and LPA
Results:
47.2% (SE: 1.2) of Americans engaged in <150min/week of MVPA and had a negative LPA-SED balance. In general, participants who engaged in ≥150min/week of MVPA, regardless of LPA-SED balance, had more favorable biological levels; however, there was evidence showing that even if individuals engaged in <150min/week of MVPA, but if their LPA exceeded SED, they had more favorable levels of triglycerides and insulin.
Conclusions:
Programs are needed to increase American's engagement in MVPA, and also ensure that LPA exceeds SED behavior.
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