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Haplophytin B from Maclurodendron porteri.

Muhammad Taher1, Deny Susanti2, Shafida Abd Hamid2

  • 1Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, Pahang, Malaysia.

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Haplophytin B, an alkaloid from Maclurodendron porteri, was isolated and identified. This compound, commonly found in the Rutaceae family, showed no antimicrobial or cytotoxic activity in preliminary tests.

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Area of Science:

  • Phytochemistry
  • Natural Product Chemistry
  • Pharmacognosy

Background:

  • Maclurodendron porteri is a plant species within the Rutaceae family.
  • Alkaloids are a diverse group of naturally occurring organic compounds that contain basic nitrogen atoms.
  • The Rutaceae family is known for its rich source of bioactive alkaloids.

Purpose of the Study:

  • To isolate and characterize a novel alkaloid from Maclurodendron porteri.
  • To determine the chemical structure of the isolated compound.
  • To evaluate the preliminary biological activities of the isolated alkaloid.

Main Methods:

  • Acid-base extraction method for initial isolation.
  • Column chromatography for purification.
  • Nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry for structural elucidation.

Main Results:

  • Haplophytin B was successfully isolated and characterized from Maclurodendron porteri.
  • The structure of the isolated compound was confirmed using spectroscopic techniques.
  • The isolated haplophytin B exhibited no inhibitory effects against Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus cereus, and Escherichia coli.
  • No cytotoxic activity was observed against H199 and A549 cell lines.

Conclusions:

  • Haplophytin B is reported for the first time in the species Maclurodendron porteri.
  • The isolated alkaloid does not possess significant antimicrobial or cytotoxic properties based on initial screening.
  • Further investigation into other potential bioactivities of haplophytin B may be warranted.