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Suitability of surgically induced chronic reflux in rats for studying esophageal carcinogenesis

Caroline Gronnier1, Guillaume Piessen, Emmanuelle Leteurtre

  • 1Department of Digestive and Oncological, Surgery, University Hospital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France, University of Lille-Nord de France, France, Inserm UMR 837, Jean Pierre Aubert, Research Center, Team 5 Mucins, Lille, France caroline.gronnier@chru-lille.fr University of Lille-Nord de France, France, Inserm UMR 837, Jean Pierre Aubert, Research Center, Team 5 Mucins, Lille, France, Centre de Biologie-Pathologie, Department of Pathology, Centre Hospitalier Régional et Universitaire, Lille, France SIRIC OncoLille University of Lille-Nord, de France, France, Inserm UMR 837, Jean Pierre Aubert, Research Center, Team 5 Mucins, Lille, France Department of Digestive and Oncological, Surgery, University Hospital Claude Huriez, Centre Hospitalier Régional Universitaire, Lille, France, SIRIC OncoLille, University of Lille-Nord, de France, France, Inserm UMR 837, Jean Pierre Aubert, Research Center, Team 5 Mucins, Lille, France.

Annals of Surgery
|December 31, 2013
PubMed
Abstract

No abstract available in PubMed .

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Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...
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