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Temporal bone pneumatization in cystic fibrosis: a correlation with genotype?
Maaike C Berkhout1, Cornelis J van Rooden, Ralph C Aalbers
1Departments of Pulmonology, Haga Teaching Hospital, the Hague, the Netherlands.
The Laryngoscope
|December 31, 2013
Summary
In cystic fibrosis (CF) patients, temporal bone pneumatization (TBP) is extensive and not linked to CF genotype or sinus volume. This suggests different influences on TBP compared to paranasal sinus pneumatization in CF.
Area of Science:
- Medical imaging
- Otolaryngology
- Genetics
Background:
- Cystic Fibrosis (CF) patients exhibit reduced paranasal sinus pneumatization, potentially linked to CF genotype.
- Conversely, CF patients show increased temporal bone pneumatization (TBP), with middle ear pathology being uncommon.
- The factors influencing TBP, whether genetic or environmental, remain debated.
Purpose of the Study:
- To investigate temporal bone pneumatization (TBP) in adult cystic fibrosis (CF) patients.
- To correlate TBP with CF genotype and paranasal sinus volume.
- To explore potential differences in pneumatization influences between the temporal bone and paranasal sinuses in CF.
Main Methods:
- Prospective data collection from 104 adult CF patients.
- Computed tomography (CT) scans of the temporal bone and paranasal sinuses were performed.
- TBP was assessed using a validated scoring system, and patients were categorized by CF transmembrane conductance regulator (CFTR) gene mutations (mild vs. severe CF).
Main Results:
- Extensive TBP was observed in 71% of mild CF patients and 82% of severe CF patients.
- No significant difference in TBP was found based on CF genotype.
- TBP did not show a correlation with paranasal sinus volume.
Conclusions:
- Unlike paranasal sinus pneumatization, TBP in CF patients is not correlated with CF genotype.
- TBP was not found to be correlated with paranasal sinus volume in this cohort.
- It is hypothesized that TBP in CF is influenced by factors distinct from those affecting paranasal sinus pneumatization.
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