[Post-synthetic modification of proteins in pathology (defective proteins)]

Process of proteins' modification under pathology are considered and classified. Attention is focused on the processes of postsynthetic modification. It is suggested not only proteins with the structure different from that in the norm to be considered as defective but also those whose biosynthesis does not provide the fulfilment of a definite function by them. Processes of proteins damaging by certain metabolites and xenobiotics are considered in detail. It is shown that all proteins of the organism may be damaged both by the excess of the natural metabolite (glucose) and by xenobiotics. The hypothesis is advanced on the important role of albumin as a primary barrier in the organism response on the chemical affection. The cooperative mechanism of the ligands' binding which underlies the detoxication function of the albumin is postulated.