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Updated: May 4, 2026
Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
Published on: October 20, 2010
Sentinel node biopsy in breast cancer using infrared laser system first experience with PDE camera
Karol Polom1, Dawid Murawa1, Michał Michalak2
11st Surgical Oncology and General Surgery Dept., Wielkopolska Cancer Centre, Garbary 15, Poznan, Poland.
Indocyanine green (ICG) offers a promising new method for sentinel lymph node biopsy (SNB) in breast cancer staging. This infrared-visible tracer demonstrated 100% sensitivity in identifying lymphatic networks and sentinel nodes.
Area of Science:
- Oncology
- Surgical Oncology
- Medical Imaging
Background:
- Sentinel node biopsy (SNB) is the standard for early breast cancer staging.
- Current SNB relies on radioactive technetium and blue dye.
- New tracers are being explored for improved lymphatic mapping.
Purpose of the Study:
- To evaluate the clinical utility of indocyanine green (ICG) for SNB.
- To compare ICG with the standard tracer, nanocoll, in breast cancer patients.
Main Methods:
- 13 female breast cancer patients underwent SNB.
- Both nanocoll and indocyanine green (ICG) were used as tracers.
- Feasibility of ICG was assessed against nanocoll.
Main Results:
- ICG allowed visualization of the lymphatic network via infrared light.
- Sentinel nodes were confirmed using a gamma probe.
- The ICG method achieved 100% sensitivity.
Conclusions:
- SNB with ICG is a promising new diagnostic technique.
- ICG offers advancements in lymphatic network diagnostics.
- While not without limitations, ICG shows significant potential.
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