Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autocrine Signaling01:01

Autocrine Signaling

42.2K
Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
42.2K
Autocrine Signaling01:01

Autocrine Signaling

3.4K
3.4K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.6K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.5K
1.5K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

4.7K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
4.7K
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

2.0K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomic Prostate Score for Identifying Biologically Low-risk Disease in Patients with Prostate Cancer Undergoing Active Surveillance, Surgery, or Radiotherapy.

European urology oncology·2026
Same author

3D pathology-guided microdissection.

Nature methods·2026
Same author

Assessing the Effects of a 3-Dimensional (3D) Pathology Tissue-Processing Workflow on Downstream Molecular Analyses.

Laboratory investigation; a journal of technical methods and pathology·2026
Same author

Germline polygenic score for prostate cancer aggressiveness.

medRxiv : the preprint server for health sciences·2026
Same author

Identification of small-molecule autophagy activators via GFP-LC3 high-throughput screening and a cargo-based autophagy flux and processing assay.

European journal of pharmacology·2026
Same author

Spatial Robustness of Prostate Cancer Biomarkers Evaluated by Spatial Transcriptomics.

The Prostate·2026

Related Experiment Video

Updated: May 4, 2026

Automated Imaging and Analysis for the Quantification of Fluorescently Labeled Macropinosomes
11:01

Automated Imaging and Analysis for the Quantification of Fluorescently Labeled Macropinosomes

Published on: August 24, 2021

2.7K

Endosomal signaling and oncogenesis.

Nikolai Engedal1, Ian G Mills2

  • 1Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway.

Methods in Enzymology
|January 1, 2014
PubMed
Summary
This summary is machine-generated.

Endosomal system proteins regulate cell growth and survival. Disruptions in endocytosis signaling pathways can lead to cancer by promoting tumor suppressor or oncogene activity.

Keywords:
AdaptorCancerEndocytosisGrowth factorSignaling

More Related Videos

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

951
A Proximal Culture Method to Study Paracrine Signaling Between Cells
08:17

A Proximal Culture Method to Study Paracrine Signaling Between Cells

Published on: August 28, 2018

9.4K

Related Experiment Videos

Last Updated: May 4, 2026

Automated Imaging and Analysis for the Quantification of Fluorescently Labeled Macropinosomes
11:01

Automated Imaging and Analysis for the Quantification of Fluorescently Labeled Macropinosomes

Published on: August 24, 2021

2.7K
Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

951
A Proximal Culture Method to Study Paracrine Signaling Between Cells
08:17

A Proximal Culture Method to Study Paracrine Signaling Between Cells

Published on: August 28, 2018

9.4K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Cancer Research

Background:

  • The endosomal system internalizes nutrients, viruses, and receptors.
  • Activated receptors and signaling molecules accumulate on endosomal membranes, influencing cellular signals.
  • Endosomal signaling platforms modulate signal potentiation and attenuation, crucial for cell growth regulation.

Purpose of the Study:

  • To discuss the role of endocytosis-regulating proteins in cancer.
  • To explore how these proteins function as tumor suppressors or oncogenes.
  • To examine the contribution of altered endosomal signaling to oncogenesis.

Main Methods:

  • Review of scientific literature on endocytosis and cancer.
  • Analysis of signaling pathways involving endosomal protein complexes.
  • Discussion of receptor tyrosine kinase regulation and its disruption in cancer.

Main Results:

  • Disruption of endosomal protein complex assembly contributes to oncogenesis.
  • Altered endosomal signaling impacts cell survival and differentiation markers.
  • Endocytosis regulators can act as tumor suppressors or oncogenes.

Conclusions:

  • The endosomal system is a critical regulator of cell signaling and growth.
  • Dysregulation of endosomal signaling pathways is implicated in cancer development.
  • Targeting endosomal protein function offers potential therapeutic strategies for cancer.