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Updated: May 4, 2026
Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors
Published on: August 18, 2016
Midtreatment evaluation of lymphoma response to chemotherapy by volume perfusion computed tomography
Daniel Spira1, Leonard Grünwald, Wichard Vogel
1From the *Department of Diagnostic and Interventional Radiology, and †Department of Oncology and Hematology, Eberhard-Karls-University, Tübingen, Germany; and ‡Finance Department, HEC Paris, Jouy en Josas, France.
Objective:
The aim of this study was to search for chemotherapy-induced perfusion changes of diffuse large B-cell lymphoma, follicular lymphoma, and Hodgkin lymphoma at midtreatment versus baseline volume perfusion computed tomography (VPCT).
Methods:
Forty-five consecutive patients with untreated diffuse large B-cell lymphoma, follicular lymphoma, and Hodgkin lymphoma received VPCT examinations of the tumor bulk at baseline and during chemotherapy (midtreatment). Blood flow (BF), blood volume (BV), and transit constant (K-trans) were determined. Treatment response was categorized according to the Cheson criteria into complete or partial remission and stable or relapsed/progressive disease.
Results:
Midtreatment follow-up showed a reduction in BF, BV, and K-trans in all lymphoma subtypes compared with baseline. The reduction in BV was less pronounced in larger tumors. Notably, BF, BV, and K-trans decreased in the responders (complete remission/partial remission) when compared with the nonresponders (stable or relapsed/progressive disease). Less than 10% reduction in BF was shown to be the best VPCT criterion for the identification of nonresponse.
Conclusions:
Chemotherapy-induced perfusion changes in responders are recognizable at midtreatment VPCT.
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