Parasite infection and tuberculosis disease among children: a case-control study
Molly F Franke1, Hernán Del Castillo, Ynés Pereda
1Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; Partners In Health/Socios En Salud Sucursal Peru, Lima, Peru; Instituto Nacional de Salud del Niño, Lima, Peru; Dartmouth Center for Health Care Delivery Science, Dartmouth College, Hanover, New Hampshire; Division of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts.
Abstract:
We conducted a case-control study to examine associations between parasite infection, including protozoa infection, and tuberculosis (TB) in children in Lima, Peru. We enrolled 189 matched-pairs. In multivariable conditional logistic regression analyses, Blastocystis hominis infection (rate ratio = 0.30, 95% confidence interval = 0.14-0.64, P = 0.002) was strongly associated with a lower risk of TB. We observed a statistically significant inverse linear dose-response relationship between Blastocystis hominis infection and TB. These findings should be confirmed in future prospective studies.
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