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Association between serum 25-hydroxyvitamin D levels and cognitive function among older adults in Tianjin, China: a
Ziyan Lou1,2,3, Xinze Han1,2,3, Xiaomin Wu1,2,3
1Department of Epidemiology & Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.
Objective:
To explore the association between serum 25-hydroxyvitamin D (25-OH-D) levels and mild cognitive impairment (MCI) and further analyse the association between serum 25-OH-D levels and different dimensions of cognitive function.
Design:
Cross-sectional study.
Setting:
Tianjin, China.
Participants:
A total of 866 participants aged 65 and above were enrolled in this study.
Outcome:
MCI was diagnosed based on the revised Petersen diagnostic criteria. Cognitive function was assessed by the Wechsler Adult Intelligence Scale Revised in China.
Results:
The prevalence of MCI was 12.0%. Higher serum 25-OH-D levels were significantly associated with lower odds of MCI, as well as with MCI across all subgroups (p<0.05). Serum 25-OH-D levels were significantly and positively associated with full intelligence quotient (FIQ), verbal intelligence quotient (VIQ), information, similarity and vocabulary (p<0.05). The associations between serum 25-OH-D levels and cognitive function did not significantly differ by age, gender or education level, with no statistical evidence of interactive effects.
Conclusion:
Higher serum 25-OH-D levels were significantly associated with lower odds of MCI. Furthermore, serum 25-OH-D levels were significantly and positively associated with different dimensions of cognitive function, specifically FIQ, VIQ, information, similarity and vocabulary. There was no statistically significant interaction observed between serum 25-OH-D levels and age, gender or education level.
