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Cellular reprogramming and hepatocellular carcinoma development.

Yun-Wen Zheng¹, Yun-Zhong Nie¹, Hideki Taniguchi¹

¹Yun-Wen Zheng, Yun-Zhong Nie, Hideki Taniguchi, Department of Regenerative Medicine, Graduate School of Medicine, Yokohama City University, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.

World Journal of Gastroenterology

|January 1, 2014

Summary

This summary is machine-generated.

Cellular reprogramming drives resistance and recurrence in hepatocellular carcinoma (HCC). Targeting this process offers a novel therapeutic strategy for liver cancer and potentially other malignancies.

Keywords:

Cancer stem cells Hepatocellular carcinomas Reprogramming Therapeutics Transcription factor

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Area of Science:

Oncology
Cancer Biology
Stem Cell Biology

Background:

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death globally.
Cellular reprogramming is increasingly recognized for its role in cancer chemoresistance and recurrence.
Aberrant expression of stemness transcription factors (OCT4, KLF4, SOX2, c-MYC, NANOG, LIN28) is linked to poor HCC outcomes.

Purpose of the Study:

To review and discuss current findings on cellular reprogramming in HCC.
To explore the mechanisms inducing reprogramming in HCC.
To introduce a novel therapeutic concept, reprogramming control therapy, for HCC treatment.

Main Methods:

Literature review and synthesis of recent research on cellular reprogramming in HCC.
Analysis of factors influencing stemness transcription factor expression.
Discussion of potential therapeutic strategies targeting cellular reprogramming.

Main Results:

Cellular reprogramming plays a critical role in HCC occurrence and recurrence.
Factors such as DNA methylation, miRNAs, tumor microenvironment, and signaling pathways induce stemness transcription factors.
Therapies targeting cellular reprogramming show potential to revolutionize HCC treatment.

Conclusions:

Cellular reprogramming is a key driver in HCC development and treatment resistance.
Reprogramming control therapy, targeting differentiation and reprogramming, presents a promising novel therapeutic avenue.
This strategy holds potential for HCC and may extend to other cancer types.