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Development and Standardization of an Ex Vivo Micromethod for Intracellular Quantification of Vincristine in Primary ALL Cells by LC-MS/MS
Published on: January 23, 2026
[Purification and identification of impurities in vinorelbine bitartrate]
Jian-Jun Huang1, Hong-Liang Chen1, Guang-Yu Huang1
1Guangzhou Baiyunshan Hanfang Pharmaceutical Company Limited, Guangzhou 510970, China.
Objective:
To investigate the chemical constituents of impurities in Vinorelbine Bitartrate.
Methods:
The impurities were isolated and purified by silica gel column chromatographies, and their structures were identified on the basis of their physicochemical properties and spectroscopic data.
Results:
Three compounds were isolated from Vinorelbine Bitartrate, and their structures were identified as Vinorelbine Bitartrate 3',4'-epoxy vinorelbine (1), 3',4'-oxidevinoerlbine (2) and 6'-N-mthyl-17-bormovinoerlbine (3).
Conclusion:
Compounds 2 and 3 are obtained as the impurities in Vinorelbine Bitartrate for the first time.
