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Additional Subnuclear Structures02:10

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The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
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Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation
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The nuclear physique.

Thoru Pederson1

  • 1Program in Cell and Developmental Dynamics, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

International Review of Cell and Molecular Biology
|January 2, 2014
PubMed
Summary
This summary is machine-generated.

This volume explores how physical phenomena impact nuclear function and design. It highlights the growing importance of physical sciences in cell biology research and education.

Keywords:
BiophysicsNuclear organizationNucleusPhysical cell biology

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Area of Science:

  • Cell Biology
  • Biophysics
  • Physical Sciences

Background:

  • Increasing awareness of the intersection between cell biology and physical sciences.
  • Physical phenomena's role in the functional design and operation of the nucleus is gaining recognition.
  • This topic was a major theme in recent American Society for Cell Biology meetings.

Purpose of the Study:

  • To present diverse perspectives on the physical underpinnings of nuclear function.
  • To underscore the interdisciplinary opportunities at the cell biology-physical sciences interface.
  • To provide a timely overview of this emerging field.

Main Methods:

  • This work is a collection of perspectives, not a single experimental study.
  • It synthesizes current understanding from various contributors.
  • The content reflects discussions and curricula from leading scientific meetings and courses.

Main Results:

  • Physical phenomena are integral to the nucleus's functional design and operation.
  • There is a significant and growing synergy between cell biology and the physical sciences.
  • This interdisciplinary approach offers new research opportunities.

Conclusions:

  • The integration of physical sciences into cell biology is crucial for understanding nuclear function.
  • The presented perspectives highlight the timeliness and relevance of this interdisciplinary field.
  • This volume serves as a valuable resource for researchers and educators.