Related Experiment Video

Updated: May 4, 2026

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
06:19

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

Published on: May 31, 2024

1.9K

Prophylactic ampicillin versus cefazolin for the prevention of post-cesarean infectious morbidity in Rwanda

Victor N Mivumbi1, Sarah E Little2, Stephen Rulisa1

  • 1Department of Obstetrics and Gynecology, National University of Rwanda Faculty of Medicine, Kigali, Rwanda; Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Kigali (CHUK), Kigali, Rwanda.

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|January 2, 2014
PubMed

Insights

Cefazolin significantly reduced postoperative infections compared to ampicillin in women undergoing cesarean delivery in Rwanda. This suggests cefazolin as a preferred prophylactic antibiotic to improve patient outcomes.

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Disease Prevention
  • Pharmacology

Background:

  • Cesarean delivery is a common surgical procedure worldwide.
  • Postoperative infections following cesarean delivery pose significant risks to maternal health.
  • Antibiotic prophylaxis is standard practice to reduce surgical site infections.

Purpose of the Study:

  • To compare the efficacy of ampicillin and cefazolin as prophylactic antibiotics before cesarean delivery.
  • To evaluate the impact of these antibiotics on postoperative infectious morbidity in Rwanda.

Main Methods:

  • A prospective, randomized, open-label study was conducted in Rwanda.
  • 132 women undergoing cesarean delivery were randomized to receive either ampicillin (n=66) or cefazolin (n=66).
  • Infectious morbidity was assessed daily during hospitalization and through follow-up within 2 weeks.

Main Results:

  • The overall infection rate was 15.9%.
  • The infection rate was significantly lower in the cefazolin group (6.1%) compared to the ampicillin group (25.8%).
  • No participants were lost to follow-up.

Conclusions:

  • Prophylactic cefazolin demonstrated superior efficacy in preventing postoperative infections compared to ampicillin.
  • Implementing cefazolin as a universal protocol could decrease febrile morbidity and reduce hospital stays.
  • Cefazolin may be a more effective choice for antibiotic prophylaxis in cesarean deliveries in similar settings.
Abstract

Keywords:
AmpicillinCefazolinCesareanInfectionProphylactic antibioticsRwanda

More Related Videos

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R2029106:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

12.0K
Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis06:09

Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis

Published on: July 18, 2017

7.7K

Related Concept Videos

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
259
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
842
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
90
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
4.7K
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
65
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
434