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Published on: May 5, 2023
Asymmetric dimethylarginine is related to the predicted stroke risk in middle-aged Japanese men
Yasuhiro Nishiyama1, Toshiaki Otsuka2, Masayuki Ueda1
1Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Background:
Asymmetric dimethylarginine (ADMA) has recently been investigated as a risk marker for cardio- and cerebrovascular diseases. However, whether ADMA levels are related to the risk of stroke in the Japanese general population remains unclear.
Methods:
We examined 769 Japanese men (mean age, 47 ± 5 years) undergoing health examinations. Each subject's ADMA level and various vascular risk factors were assessed; the predicted 10-year stroke risk was calculated using the point-based prediction model from the Japan Public Health Center Study.
Results:
In a multiple linear regression analysis, age, body mass index, estimated glomerular filtration rate, and current smoking status were significant independent determinants of ADMA levels. A significant odds ratio (OR) for high predicted stroke risk (10-year risk ≥ 5%)was noted in the highest quartile of ADMA levels (OR, 2.47; 95% CI, 1.002-6.07), compared with the lowest quartile, after adjusting for potential confounding factors. A significant OR for high predicted stroke risk was also found for each standard deviation increment in ADMA level (adjusted OR, 1.46; 95% CI, 1.10-1.92).
Conclusion:
Elevated ADMA levels were significantly associated with an increased predicted stroke risk, suggesting that measuring ADMA levels may be useful for identifying middle-aged Japanese men with a high risk of stroke.
Insights
Elevated asymmetric dimethylarginine (ADMA) levels are linked to higher predicted stroke risk in Japanese men. Measuring ADMA may help identify individuals needing closer monitoring for stroke prevention.
Area of Science:
- Cardiovascular Research
- Stroke Epidemiology
- Biomarker Discovery
Background:
- Asymmetric dimethylarginine (ADMA) is a potential risk marker for cardiovascular and cerebrovascular diseases.
- The association between ADMA levels and stroke risk in the Japanese general population is not well-established.
Purpose of the Study:
- To investigate the relationship between ADMA levels and predicted stroke risk among Japanese men.
- To determine if ADMA can serve as a useful biomarker for identifying high-stroke-risk individuals.
Main Methods:
- A cohort of 769 Japanese men (mean age 47 years) was studied.
- ADMA levels and vascular risk factors were assessed.
- Predicted 10-year stroke risk was calculated using the Japan Public Health Center Study model.
Main Results:
- Age, BMI, eGFR, and smoking status independently determined ADMA levels.
- The highest quartile of ADMA levels was associated with a 2.47-fold increased odds of high predicted stroke risk.
- Each standard deviation increase in ADMA was linked to a 1.46-fold increased adjusted odds of high predicted stroke risk.
Conclusions:
- Elevated ADMA levels are significantly associated with increased predicted stroke risk in middle-aged Japanese men.
- ADMA measurement may be a valuable tool for stroke risk stratification in this population.
