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Flavivirus entry receptors: an update

Manuel Perera-Lecoin1, Laurent Meertens2, Xavier Carnec3

  • 1INSERM U944, CNRS 7212, Laboratoire de Pathologie et Virologie Moléculaire, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, Paris 75010, France. manuel.perera@inserm.fr.

Viruses
|January 2, 2014
PubMed

Insights

Flaviviruses use specific cell surface receptors for entry into host cells. This review details C-type lectin and phosphatidylserine receptors, like TIM and TAM, crucial for flavivirus attachment and infection.

Area of Science:

  • Virology
  • Cell Biology
  • Immunology

Background:

  • Flaviviruses initiate host cell entry via endocytosis.
  • Viral entry involves attachment factors and primary receptors directing viruses to endocytic pathways.

Purpose of the Study:

  • To review current knowledge on flavivirus receptors.
  • To focus on C-type lectin and phosphatidylserine receptors (TIM and TAM) in flavivirus entry.

Main Methods:

  • Literature review of published studies on flavivirus-receptor interactions.
  • Analysis of the roles of specific receptor families in viral attachment and entry.

Main Results:

  • Flaviviruses utilize multiple receptor types for cell surface attachment and internalization.
  • C-type lectin receptors and phosphatidylserine receptors (TIM, TAM) are key players in flavivirus infection.

Conclusions:

  • Understanding flavivirus receptors is crucial for comprehending viral pathogenesis.
  • Specific receptors like TIM and TAM offer potential targets for antiviral strategies.

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