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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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Updated: May 4, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
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Epigenetics in breast cancer.

C Atalay1

  • 1Department of General Surgery, Ankara Oncology Hospital, Ankara 06200, Turkey.

Experimental Oncology
|January 3, 2014
PubMed
Summary

Epigenetic modifications like DNA methylation are key in breast cancer research. New diagnostic markers and therapeutic targets are emerging from these studies.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Epigenetic information is increasingly recognized for its role in cancer.
  • Epigenetics in breast cancer is a rapidly developing field.
  • DNA methylation and histone acetylation are well-studied epigenetic modifications in breast cancer.

Purpose of the Study:

  • To explore the evolving role of epigenetics in breast cancer.
  • To highlight the development of novel methods for detecting epigenetic changes.
  • To discuss the potential of epigenetic modifications as diagnostic, prognostic, and therapeutic targets in breast cancer.

Main Methods:

  • Evaluation of established epigenetic modifications (DNA methylation, histone acetylation).
  • Development and application of novel, high-specificity methods for detecting epigenetic alterations.

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  • Analysis of epigenetic markers for breast cancer diagnosis and prognosis.
  • Investigation of epigenetic modifications as therapeutic targets.

    • Main Results:

    • New methods offer higher specificity in detecting epigenetic changes.
    • Emerging epigenetic markers show promise for breast cancer diagnosis and prognosis.
    • Epigenetic modifications are being explored as novel therapeutic targets.

    Conclusions:

    • Epigenetic modifications represent a significant area of research in breast cancer.
    • Advanced detection methods are crucial for identifying new biomarkers.
    • Targeting epigenetic alterations offers potential for improved breast cancer treatment strategies, including combination therapies.