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Updated: May 4, 2026

Analysis of Hematopoietic Stem Progenitor Cell Metabolism
Published on: November 9, 2019
Guardian of the furnace: mitochondria, TRAP1, ROS and stem cell maintenance
Rose Kadye1, Adam H Kramer, Julia Joos-Vandewalle
1Biomedical Biotechnology Research Unit, Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, Grahamstown, South Africa.
Abstract:
Mitochondria are key to eukaryotic cell survival and their activity is linked to generation of reactive oxygen species (ROS) which in turn acts as both an intracellular signal and an effective executioner of cells with regards to cellular senescence. The mitochondrial molecular chaperone tumor necrosis factor receptor associated protein 1 (TRAP1) is often termed the cytoprotective chaperone for its role in cancer cell survival and protection from apoptosis. Here, we hypothesize that TRAP1 serves to modulate mitochondrial activity in stem cell maintenance, survival and differentiation.
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