Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

3.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.2K
Structural Joints: Synovial Joints01:16

Structural Joints: Synovial Joints

8.0K
Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
8.0K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

13.7K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
13.7K
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

41
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
41
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

10.2K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
10.2K
Introduction to Fibroblasts01:09

Introduction to Fibroblasts

3.9K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A perspective on In vitro developmental neurotoxicity test assay results: An expert panel review.

Regulatory toxicology and pharmacology : RTP·2023
Same author

Interleukin (IL)-17A, F and AF in inflammation: a study in collagen-induced arthritis and rheumatoid arthritis.

Clinical and experimental immunology·2014
Same author

Divergence of the systemic immune response following oral infection with distinct strains of Porphyromonas gingivalis.

Molecular oral microbiology·2012
Same author

Lead-induced Alterations in Gene Expression and Activity of Retinal cGMP PDE Results in Calcium Overload and Rod-selective Apoptosis.

Toxicology in vitro : an international journal published in association with BIBRA·2010
Same author

The role of T helper type 17 cells in inflammatory arthritis.

Clinical and experimental immunology·2009
Same author

Pharmacological strategies to block rod photoreceptor apoptosis caused by calcium overload: a mechanistic target-site approach to neuroprotection.

European journal of ophthalmology·2003

Related Experiment Video

Updated: May 4, 2026

A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation
09:48

A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation

Published on: June 2, 2022

2.8K

Interactions between T cells and synovial fibroblasts.

Y Yamamura1, E Shelden, D A Fox

  • 1Division of Rheumatology, Department of Internal Medicine, and Multipurpose Arthritis and Musculoskeletal Diseases Center, University of Michigan , 5520 MSRBI, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0680 , USA.

Modern Rheumatology
|January 4, 2014
PubMed
Summary

Interactions between T lymphocytes and synovial fibroblasts are crucial in rheumatoid arthritis. Cell-cell contact may activate these cells, significantly impacting joint inflammation and destruction in rheumatoid arthritis.

More Related Videos

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
09:18

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

8.4K

Related Experiment Videos

Last Updated: May 4, 2026

A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation
09:48

A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation

Published on: June 2, 2022

2.8K
Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
09:18

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

8.4K

Area of Science:

  • Immunology
  • Rheumatology
  • Cell Biology

Background:

  • Rheumatoid arthritis (RA) involves T lymphocytes, synovial macrophages, and synovial fibroblasts in joint inflammation.
  • Interactions between T cells-macrophages and macrophages-fibroblasts are well-studied in RA pathogenesis.
  • The role of direct T lymphocyte-synovial fibroblast interactions in RA remains less explored.

Purpose of the Study:

  • To review existing data on T lymphocyte-synovial fibroblast interactions in rheumatoid arthritis.
  • To highlight the potential significance of these interactions in RA pathophysiology.
  • To emphasize the need for further research into this specific cell-cell communication.

Main Methods:

  • Literature review of studies investigating T lymphocyte and synovial fibroblast interactions.
  • Analysis of data on cell-cell contact mechanisms and their effects.
  • Synthesis of findings related to the role of these interactions in rheumatoid arthritis.

Main Results:

  • Evidence suggests direct cell-cell contact between T lymphocytes and synovial fibroblasts can activate both cell types.
  • This interaction may contribute to the inflammatory processes in rheumatoid arthritis synovial tissue.
  • Synovial fibroblasts and T lymphocytes are key players in RA, and their direct interaction warrants attention.

Conclusions:

  • Direct interaction between T lymphocytes and synovial fibroblasts is a potentially significant factor in rheumatoid arthritis.
  • This cell-cell contact may drive disease pathogenesis through mutual activation.
  • Further investigation into this interaction is crucial for understanding and treating rheumatoid arthritis.