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German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
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Quantification of bone volume on radiographs using NIH Image.

R Nagamine1, Y Hanada, M Kondo

  • 1Department of Orthopaedic Surgery, Postgraduate School of Medical Sciences, Kyushu University , 3-1-1 Maidashi, Higashi-ku, Fukuoka , Japan.

Modern Rheumatology
|January 4, 2014
PubMed
Summary
This summary is machine-generated.

This study quantifies periarticular bone atrophy in rheumatoid arthritis (RA) patients using NIH Image software. The brightness/darkness index (BDI) effectively measures bone volume loss, particularly in younger RA patients.

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Area of Science:

  • Radiology
  • Orthopedics
  • Rheumatology

Background:

  • Rheumatoid arthritis (RA) is a chronic inflammatory disease that can lead to bone loss.
  • Quantifying periarticular bone atrophy in RA patients is crucial for monitoring disease progression and treatment efficacy.
  • Existing methods for assessing bone atrophy may lack precision or accessibility.

Purpose of the Study:

  • To quantify periarticular bone atrophy in the proximal phalanx of rheumatoid arthritis (RA) patients.
  • To evaluate the utility of the National Institutes of Health (NIH) Image computer program for this quantification.
  • To establish a reliable index for bone volume assessment in RA.

Main Methods:

  • Utilized the NIH Image computer program to analyze radiographs of the proximal phalanx.
  • Measured the brightness/darkness index (BDI) in 20x20 pixel squares within the bone.
  • Defined BDI as a measure of bone volume, with 0 representing complete darkness and 255 maximum brightness.

Main Results:

  • The mean BDI was significantly lower in RA patients (100 at diaphysis midpoint, 75 at proximal end) compared to normal volunteers (176 and 145, respectively).
  • The difference in BDI was most pronounced in younger individuals.
  • Low BDI values at the proximal end clearly indicated periarticular bone atrophy in some young RA patients.

Conclusions:

  • Periarticular bone atrophy in RA patients can be reliably quantified using the NIH Image computer program.
  • The brightness/darkness index (BDI) serves as an effective measure of bone volume in RA.
  • This quantitative approach offers a valuable tool for assessing bone changes in rheumatoid arthritis.