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[Cholestatic icterus during parenteral feeding in the newborn ano infants]
Insights
Parenteral nutrition can cause cholestatic jaundice in infants. Interrupting nutrition led to jaundice regression in three survivors, suggesting a link between parenteral feeding and liver issues.
Area of Science:
- Pediatrics
- Neonatology
- Gastroenterology
Background:
- Parenteral alimentation is a critical nutritional support for newborns and infants unable to receive adequate nutrition orally.
- Cholestatic jaundice is a potential complication in infants receiving prolonged parenteral nutrition.
Observation:
- Six cases of cholestatic jaundice were observed in infants receiving parenteral alimentation.
- In four cases, underlying conditions like duodenal atresia, necrotizing enteritis, or mucoviscidosis were contributing factors.
- In two cases, parenteral alimentation itself appeared to be a primary cause, particularly with excessive and imbalanced amino acid administration.
Findings:
- Three out of six infants survived the condition.
- Jaundice regressed within 15 days to three weeks after discontinuing parenteral alimentation.
- The study highlights a correlation between parenteral nutrition and the development of cholestatic jaundice in vulnerable infants.
Implications:
- This suggests careful monitoring of liver function is crucial in infants receiving parenteral nutrition.
- Optimizing amino acid composition and administration may mitigate the risk of parenteral nutrition-associated cholestasis.
- Early recognition and management, including potential interruption of parenteral nutrition, can lead to favorable outcomes.
Abstract:
The authors observed six cases of cholestatis jaundice occuring during parenteral alimentation in the newborn and the infant. In 4 cases, local factors (duodenal atresia, necrosing enteritis of prematurity) or general factors (mucoviscidosis) probably played an essential role. In two cases, the parenteral alimentation seemed to be a main factor, but in one case with excessive and imbalanced supplies of amino acids. Three patients survived, with regression of the jaundice in 15 days to three weeks following the interruption of parenteral alimentation.