Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response heterogeneity in a randomized controlled trial of telerehabilitation interventions among adults with multiple sclerosis.

Journal of telemedicine and telecare·2020
Same author

Response.

Medicine and science in sports and exercise·2020
Same author

Push-Rate Threshold for Physical Activity Intensity in Persons Who Use Manual Wheelchairs.

American journal of physical medicine & rehabilitation·2020
Same author

Examining Multilevel Environmental Correlates of Physical Activity Among Older Adults With Multiple Sclerosis.

Journal of aging and physical activity·2020
Same author

Development and Cross-Validation of a Prediction Equation for Estimating Percentage Body Fat From Body Mass Index in Young People With Intellectual Disability.

Adapted physical activity quarterly : APAQ·2020
Same author

The experience and meaning of aging with multiple sclerosis: An existential phenomenological approach.

Journal of aging studies·2020

Related Experiment Video

Updated: May 4, 2026

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.9K

Step-rate thresholds for physical activity intensity in persons with multiple sclerosis.

Stamatis Agiovlasitis1, Robert W Motl

  • 1Department of Kinesiology at Mississippi State University.

Adapted Physical Activity Quarterly : APAQ
|January 4, 2014
PubMed
Summary

Activity intensity thresholds are altered for individuals with multiple sclerosis (MS). Lower step-rate thresholds for metabolic equivalent units (METs) were observed in MS patients, particularly those with greater walking impairment.

More Related Videos

A Method for Quantifying Upper Limb Performance in Daily Life Using Accelerometers
07:24

A Method for Quantifying Upper Limb Performance in Daily Life Using Accelerometers

Published on: April 21, 2017

13.2K
Assessment of Physical Activity Intensity with Accelerometers and Oxygen Consumption
08:45

Assessment of Physical Activity Intensity with Accelerometers and Oxygen Consumption

Published on: June 20, 2025

772

Related Experiment Videos

Last Updated: May 4, 2026

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.9K
A Method for Quantifying Upper Limb Performance in Daily Life Using Accelerometers
07:24

A Method for Quantifying Upper Limb Performance in Daily Life Using Accelerometers

Published on: April 21, 2017

13.2K
Assessment of Physical Activity Intensity with Accelerometers and Oxygen Consumption
08:45

Assessment of Physical Activity Intensity with Accelerometers and Oxygen Consumption

Published on: June 20, 2025

772

Area of Science:

  • Exercise Physiology
  • Neurology
  • Rehabilitation Science

Background:

  • The relationship between physical activity intensity and physiological responses like metabolic equivalent units (METs) is crucial for exercise prescription.
  • Multiple Sclerosis (MS) can affect mobility and potentially alter the relationship between physical exertion metrics and energy expenditure.
  • Establishing accurate activity intensity thresholds is vital for safe and effective exercise programming in individuals with MS.

Purpose of the Study:

  • To investigate if the relationship between metabolic equivalent units (METs) and step-rate differs in individuals with multiple sclerosis (MS) compared to healthy controls.
  • To develop specific step-rate thresholds for defining activity intensity levels (e.g., 3 and 6 METs) for persons with MS.
  • To examine how varying levels of walking impairment in MS influence these step-rate thresholds.

Main Methods:

  • Participants included 24 individuals with MS (categorized into minimal and mild-moderate walking impairment subgroups based on MSWS-12) and 24 healthy controls.
  • Metabolic equivalent units (METs) were measured using spirometry.
  • Step-rate was recorded using a hand-tally method.
  • Statistical analysis examined predictors of METs, including step-rate, height, group, and their interactions.

Main Results:

  • Step-rate, height, group status, the interaction between step-rate and group, and the square of step-rate were significant predictors of METs.
  • Individuals with MS exhibited lower step-rate thresholds for achieving 3 and 6 METs compared to healthy controls.
  • These step-rate thresholds were progressively lower in the mild-moderate walking impairment MS subgroup compared to the minimal impairment subgroup.

Conclusions:

  • The relationship between METs and step-rate is significantly altered in individuals with MS.
  • Persons with MS require a lower step-rate to achieve specific activity intensity levels (METs), with greater impairment leading to lower thresholds.
  • These findings necessitate adjusted step-rate guidelines for exercise intensity prescription in the MS population to ensure appropriate and safe physical activity.