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Fabrication of the Composite Regenerative Peripheral Nerve Interface C-RPNI in the Adult Rat
Published on: February 25, 2020
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Tissue engineered constructs for peripheral nerve surgery
P J Johnson1, M D Wood1, A M Moore1
1Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, 660 South Euclid, 8238, Saint Louis, MO 63110, USA.
European Surgery : ACA : Acta Chirurgica Austriaca
|January 4, 2014
Summary
Tissue engineering aims to create nerve substitutes for traumatic injuries, using scaffolds and cells to bridge damaged peripheral nerves and promote axon regeneration.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Neuroscience
Background:
- Peripheral nerve injuries with significant tissue loss require solutions for axon regeneration.
- Tissue engineering offers a promising approach to develop biological substitutes for nerve repair.
Purpose of the Study:
- To review the essential components for creating tissue-engineered peripheral nerve substitutes.
- To present a comprehensive overview of studies focused on developing these nerve substitutes.
Main Methods:
- Literature review to identify key components for tissue-engineered nerve substitutes.
- Comprehensive literature synthesis of existing research in this domain.
Main Results:
- Tissue-engineered nerve substitutes ideally comprise a scaffold mimicking the native extracellular matrix.
- A cellular component is crucial for stimulating and supporting regenerating axons.
Conclusions:
- The field must aim to surpass autograft outcomes by understanding nerve regeneration drivers and inhibitors.
- Tissue engineering challenges include not only matching but exceeding the gold standard of autografts.
Keywords:
Acellular nerve allograftNerve conduitsNeural crest cellsPeripheral nerve surgeryStem cellsTissue engineering
