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Updated: May 4, 2026
Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
Published on: March 20, 2026
New biological treatments for gynecological tumors: focus on angiogenesis
Gennaro Daniele1, Massimo Di Maio, Maria Carmela Piccirillo
1Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale", IRCCS, Clinical Trials Unit , Via M. Semmola, 80131, Napoli , Italy +39 081 593 571 ; +39 081 770 2938 ; f.perrone@istitutotumori.na.it , francesco.perrone@usc-intnapoli.net.
Introduction:
Gynecological tumors are a group of heterogeneous malignancies, with only modest results having been observed thus far with chemotherapy in advanced disease. New insights from pathobiology of these tumors have shed new light on potential new therapeutic targets. Angiogenesis is one of the most important processes involved in tumorigenesis, and effective treatments targeting the angiogenic machinery are now available.
Areas Covered:
In this review, we will focus on angiogenesis as a therapeutic target in gynecological cancer patients. After a brief introduction on the angiogenesis machinery involvement in these malignancies, the most recent clinical data will be discussed.
Expert Opinion:
Although clinical data with antiangiogenics are groundbreaking in several tumors such as ovarian epithelial cancer, overall efficacy of these agents is far from what was initially envisaged. As with other molecular targeted agents, selection of patients who may benefit from these agents will surely contribute to demonstrating better results. However, this does not diminish the clinical relevance of the above-mentioned results in a difficult field such as gynecological malignancies.
Insights
Targeting angiogenesis in gynecological cancers shows promise, but patient selection is key for better outcomes. Antiangiogenic therapies offer new hope in treating these challenging malignancies.
Area of Science:
- Oncology
- Molecular Biology
- Gynecologic Oncology
Background:
- Gynecological tumors are diverse malignancies with limited chemotherapy success in advanced stages.
- Pathobiology insights reveal novel therapeutic targets, including angiogenesis.
- Angiogenesis, crucial for tumor growth, is a validated therapeutic target with available treatments.
Purpose of the Study:
- To review angiogenesis as a therapeutic target in gynecological cancer.
- To discuss the involvement of the angiogenesis machinery in these cancers.
- To present recent clinical data on antiangiogenic therapies.
Main Methods:
- Review of scientific literature on angiogenesis in gynecological cancers.
- Focus on the role of angiogenesis in tumorigenesis.
- Analysis of current clinical data for antiangiogenic agents.
Main Results:
- Antiangiogenic therapies have shown groundbreaking results in specific gynecological tumors like ovarian epithelial cancer.
- The overall efficacy of antiangiogenic agents has not fully met initial expectations.
- Patient selection is crucial for optimizing the benefits of these targeted therapies.
Conclusions:
- Antiangiogenic agents demonstrate clinical relevance in gynecological malignancies.
- Improved patient selection will likely enhance the efficacy of antiangiogenic therapies.
- Despite challenges, these targeted approaches represent significant advancements in treating difficult gynecological cancers.
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