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Updated: May 4, 2026

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
Published on: June 20, 2019
Synthesis of nanometer-sized rod-coil block copolymers
Hannah M König1, Andreas F M Kilbinger2
1Department of Chemistry University of Fribourg Chemin du Musée 9 CH-1700 Fribourg, Switzerland.
Abstract:
We present the solid-supported synthesis of a linear rigid rod-like tetradeca(p-benzamide) nanorod as well as a pentadeca( p -benzamide) nanorod carrying an amide N-hexyl side chain at the center of the rod (on the 8(th) amino acid of the molecule). These nanorods were conjugated with solubilizing poly(ethylene glycol) chains and their solution aggregation was investigated. Both rod-coil block copolymers form soluble aggregates even in polar aprotic solvents such as DMF and DMSO. We show that sequence-controlled nanometer-sized shape persistent aramide scaffolds can readily be prepared using solid-supported synthesis.
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