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Microbiome in parturition and preterm birth

Indira U Mysorekar1, Bin Cao1

  • 1Department of Obstetrics and Gynecology.

Seminars in Reproductive Medicine
|January 7, 2014
PubMed

Insights

The microbiome, including vaginal and oral, significantly impacts preterm birth. Host genetics may also disrupt the pregnancy microbiome, leading to adverse outcomes.

Area of Science:

  • Microbiology
  • Obstetrics
  • Genetics

Background:

  • Preterm parturition is a major global maternal-child health concern.
  • The microbiome's role in human health and disease is increasingly recognized.
  • Understanding the microbiome's influence on pregnancy is crucial.

Purpose of the Study:

  • To review the current understanding of the microbiome's impact on parturition, focusing on preterm birth.
  • To explore the roles of vaginal and oral microbiomes in premature parturition.
  • To discuss the potential placental microbiome and host genetic influences on pregnancy outcomes.

Main Methods:

  • Literature review of microbiome studies related to parturition.
  • Focus on state-of-the-art methodologies in microbiome research.
  • Analysis of emerging research on placental microbiome and host genetics.

Main Results:

  • Vaginal and oral microbiomes are implicated in preterm birth.
  • The placenta may harbor its own microbiome, influencing pregnancy.
  • Host genetic factors can alter the pregnancy microbiome.

Conclusions:

  • The microbiome plays a significant role in preterm birth.
  • Further research into the placental microbiome and host-microbiome interactions is warranted.
  • Targeting the microbiome may offer new strategies for preventing preterm birth.

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