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Acid-base transport in pancreas-new challenges
Ivana Novak1, Kristian A Haanes1, Jing Wang1
1Department of Biology, University of Copenhagen Copenhagen, Denmark.
Frontiers in Physiology
|January 7, 2014
Summary
This review explores how acid-base transport mechanisms in the pancreas, including novel transporters and local regulators, are crucial for HCO3- and fluid secretion. Dysregulation may link to pancreatic diseases like cystic fibrosis and cancer.
Area of Science:
- Physiology
- Cell Biology
- Gastroenterology
Background:
- Epithelia along the gastrointestinal tract secrete acid or base to aid digestion.
- The stomach and pancreas exemplify extreme acid (H+) and base (HCO3-) transport, respectively.
- Both organs face challenges in transporting these substances and maintaining intracellular pH.
Purpose of the Study:
- To use comparative physiology to explain the cellular mechanisms of pancreatic HCO3- and fluid secretion.
- To highlight novel transporters and local regulators involved in pancreatic secretion.
- To explore the potential role of acid-base transport dysregulation in pancreatic diseases.
Main Methods:
- Comparative physiology review.
- Analysis of cellular mechanisms.
- Speculative analysis of disease links.
Main Results:
- Pancreatic HCO3- and fluid secretion involve complex cellular mechanisms.
- Novel transporters like H+-K+-ATPases and Ca2+-activated channels (KCa3.1, TMEM16A/ANO1) are relevant.
- Purinergic signaling acts as a local regulator of pancreatic secretion.
Conclusions:
- Understanding pancreatic acid-base transport is key to deciphering digestive physiology.
- Novel transporters and signaling pathways offer new insights into pancreatic function.
- Dysregulation of acid-base transport is a potential contributing factor to pancreatic diseases such as cystic fibrosis, pancreatitis, and cancer.
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