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Updated: May 4, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
Complement factor B polymorphism (rs641153) and susceptibility to age-related macular degeneration: evidence from
Xin Wang1, Ying Zhang1, Mao-Nian Zhang1
1Department of Ophthalmology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Aim:
To determine whether single nucleotide polymorphism (SNP) rs641153 is associated with the risk of age-related macular degeneration (AMD), we performed a systematic meta-analysis of 15 eligible studies. SNP in the complement factor B (CFB) gene is considered to have significant association with AMD susceptibility, but there is great discrepancy in these results.
Methods:
The eligible studies were identified by searching the databases of PubMed, EMBASE, and Web of Science. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association. All data were analyzed using Stata software.
Results:
The association between rs641153 and AMD risk was statistically significant under the homozygous model (AA vs GG:OR=0.26, 95%CI=0.15-0.45, P h=0.973, I (2)=0.0%, fixed effects), dominant model (AA+GA vs GG:OR=0.49, 95%CI=0.40-0.59, P h=0.004, I (2)=56.4%, random effects) and recessive model (AA vs GA+GG:OR=0.30, 95%CI=0.17-0.51, P h=0.983, I (2)=0.0%, fixed effects). The same results were also observed in the stratified analyses by ethnicity, source of control and sample size.
Conclusion:
Our meta-analysis suggests that rs641153 in the CFB gene may play a protective role in AMD susceptibility, the late AMD in particular, both in Caucasians and in Asians.
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