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Total synthesis of (+)-seimatopolide A

Kavirayani R Prasad1, Omkar Revu

  • 1Department of Organic Chemistry, Indian Institute of Science , Bangalore 560012, Karnataka, India.

The Journal of Organic Chemistry
|January 8, 2014
PubMed

Abstract:

Total synthesis of 10-membered lactone (+)-seimatopolide A is presented from furfural. Key reactions in the present strategy include the effective use of furan as a E-but-2-ene-1,4-dione surrogate, Nagao acetate aldol reaction, and Shiina lactonization.

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