Related Experiment Video
Updated: May 4, 2026
11:16
Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells
Published on: February 15, 2019
7.1K
Spontaneous and experimental malignancies in non-human primates
Boris A Lapin1, Lelita A Yakovleva
1Research Institute of Medical Primatology RAMS, Sochi-Adler, Russia.
Journal of Medical Primatology
|January 8, 2014
Summary
Monkey tumors are a frequent occurrence, not rare as previously thought, with incidence increasing with age. Hematopoietic system tumors are most common, and viral and chemical agents can induce neoplasms in primates.
Area of Science:
- Primate oncology
- Virology
- Carcinogenesis
Background:
- Previously, tumors in monkeys were considered rare.
- Recent extensive data indicate that monkey tumors are a frequent phenomenon.
- Tumor incidence in primates shows a clear correlation with increasing age.
Purpose of the Study:
- To investigate the frequency and types of tumors in monkeys.
- To identify potential etiological agents, including viruses and chemical substances.
- To explore the role of viruses in primate neoplasm development.
Main Methods:
- Analysis of a large dataset of monkey tumors.
- Isolation and characterization of viruses from affected monkeys (simian T-lymphotropic virus type 1 - STLV-1, herpesvirus papio - HVP).
- Experimental inoculation of isolated viruses into monkeys and rabbits to induce neoplasms.
Main Results:
- Tumors are frequent in monkeys, with incidence rising with age.
- Tumors of the hematopoietic system are the most common.
- Isolated viruses (STLV-1, HVP) induced neoplasms upon inoculation; neoplasms can also be induced by chemical agents and other viruses, indicating limited species specificity.
Conclusions:
- Monkey tumors are a common issue, contrary to prior beliefs.
- Viruses, such as STLV-1 and HVP, play a significant role in primate neoplasm development.
- Further research into polyomaviruses and other oncogenic agents is warranted for understanding primate cancer etiology.
Related Concept Videos
01:51Mechanisms of Retrovirus-induced Cancers
5.2K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.2K
02:43Mouse Models of Cancer Study
4.7K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
4.7K